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KMID : 0191120000150050545
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Journal of Korean Medical Science
2000 Volume.15 No. 5 p.545 ~ p.550
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Sebaceous carcinoma of the eyelids: frequent expression of c-erbB-2 oncoprotein
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Cho KJ
Khang SK/Koh JS/Chung JH/Lee SS
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Abstract
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Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented.
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